San Francisco 49ers running back Christian McCaffrey was ruled out for the remainder of the game against the Buffalo Bills after suffering a knee injury during the first quarter. The injury occurred when McCaffrey was tackled following a short reception. He immediately left the field, and the 49ers announced he would not return. This news sent shockwaves through social media and NFL circles, as McCaffrey has been a key player for the 49ers this season. ESPN’s Jenna Laine reported that McCaffrey appeared to favor his right leg while being assisted off the field. Head coach Kyle Shanahan said, “It’s tough to lose a guy like Christian, who has been pivotal for us.” Fans and analysts alike reacted strongly on Twitter, with many expressing concern about the implications of McCaffrey’s injury for the 49ers’ playoff hopes. The game concluded with the Bills winning 31-21, further adding to the 49ers’ woes as they strive for postseason success.